Europa League Draw: Arsenal will be hoping to get their hands on this trophy in May
The Gunners - who suffered a scare to progress against Ostersunds in the round of 32 - will travel to the San Siro for the first leg on Thursday, March 8.
The second leg takes place at the Emirates Stadium the following week on Thursday, March 15.
It is the standout tie of the last-16 but Arsene Wenger will be hoping his side have enough in the tank to progress to the quarter-final stage.
Meanwhile, Chelsea loanee Michy Batshuayi will face Salzburg after Borussia Dortmund drew the Austrian club.
Express Sport brought you all the action from Nyon including the last-16 draw in full.
Europa League last-16 draw
AC Milan vs Arsenal
12.25: So Arsenal are drawn against AC Milan.
It could have been worse but it could have been better.
It might initially look like a tough tie for Arsenal but Milan aren’t the dominant force of Italian football they once were.
They are currently seventh in the Serie A table with 41 points from 25 games - 25 points behind leaders Napoli.
Last summer’s splurge in the transfer market hasn’t quite paid dividends but they’re starting to hit some form under Gennaro Gattuso.
Europa League last-16 draw
Dynamo Kiev vs Lazio
Leipzig vs Zenit
Atletico Madrid vs Lokomotiv Moscow
CSKA Moscow vs Lyon
Marseille vs Athletic Bilbao
Sporting Lisbon vs Plzen
Borussia Dortmund vs Salzburg
AC Milan vs Arsenal
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AC Milan chief Massimiliano Mirabelli says he feels "sorry for Arsenal" after they were drawn against the Italian giants in the last 16 of the Europa League.
Mirabelli added that he's sure the north London club 'would have liked to have continued in Europe', suggesting their campaign is about to come to an end.
Arsenal scraped through their round of 32 tie against Ostersunds FK, who they battered 3-0 in Sweden in the first leg.
Graham Potters' men stunned them in the second leg at the Emirates, storming into a two-goal lead before the break.
(Image: Getty Images Europe)
Sead Kolasinac ensured the Gunners would be going through however, with a second half strike, as Arsenal ran out 4-2 winners on aggregate.
Arsene Wenger's men learned their last-16 fate on Friday, and will now prepare for the challenge of AC Milan.
(Image: Arsenal FC)
But it seems AC Milan chief Mirabelli is supremely confident the Italians already have the result in the bag.
"I'm sorry for Arsenal, who I'm sure would have liked to have continued in Europe," said Mirabelli.
(Image: Getty Images Europe)
"It would have been a nice final, but I'm happy. It's best to face a big club like Arsenal now. We needed opponents like these."
Milan's club manager Christian Abbiati told Sky Sport Italia: "Facing Arsenal is a fascinating encounter. It's bound to be a great tie."
(Image: REUTERS)
Abbiati was in goal for AC Milan in both legs of Arsenal's last-16 Champions League clash with the Italian club back in 2012.
Milan won the first game 4-0 at the San Siro before they were thumped 3-0 away.
(Image: AFP)
Recalling the second leg, while looking ahead to the test facing this Milan side, Abbiati said: "It was a disaster at London, where we lost 3-0, but in the end, we made it through.
"I hope we don't see the same mistakes this time. Milan are in good form at the moment with some good results and I hope we can keep it up."
